Reaction: ALDHs oxidise atRAL to atRA
- in pathway: RA biosynthesis pathway
Several aldehyde dehydrogenases catalyse the irreversible oxidation of retinal to retinoic acid. ALDH1A1, 2 and 3 utilise NAD+ as cofactor to oxidise all-trans-retinal (atRAL) to all-trans-retinoic acid (atRA). They are cytosolic enzymes which are functional in their homotetrameric states (Yoshida et al. 1993, Duester 2008, Bchini et al. 2013).
Reaction - small molecule participants:
H+ [cytosol]
atRA [cytosol]
NADH [cytosol]
H2O [cytosol]
atRAL [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-5362522
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Reaction input - small molecules:
water
all-trans-retinal
NAD(1-)
Reaction output - small molecules:
hydron
all-trans-retinoic acid
NADH(2-)
Reactome.org link: R-HSA-5362522