Reaction: ADH1A,1C,4 oxidise atROL to atRAL in vitro
- in pathway: RA biosynthesis pathway
Some alcohol dehydrogenases (ADHs) utilise NAD+ as cofactor to reversibly oxidise all-trans-retinol (atROL) to all-trans-retinal (atRAL), a retinoid aldehyde, in vitro (von Bahr-Lindstrom et al. 1986, Ikuta et al. 1986, von Bahr-Lindstrom et al. 1991, Xie et al. 1997). ADH1A (ADH1) and ADH4 have high activity and ADH1C (ADH3) has low activity with non-physiological amounts of retinol in vitro. ADH1A and ADH1C metabolize toxic amounts of retinol in vivo, but ADH4 does not. Physiological contributions of ADHs to retinol metabolism have not been demonstrated, in contrast to RDHs.
Reaction - small molecule participants:
H+ [cytosol]
atRAL [cytosol]
NADH [cytosol]
atROL [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-5362564
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Reaction input - small molecules:
all-trans-retinol
NAD(1-)
Reaction output - small molecules:
hydron
all-trans-retinal
NADH(2-)
Reactome.org link: R-HSA-5362564