Reaction: RDH5,RDH11 oxidise 11cROL to 11cRAL
- in pathway: RA biosynthesis pathway
11-cis-retinol dehydrogenase (RDH5) and RDH11 catalyse the final step in the biosynthesis of 11-cis-retinal (11cRAL), the universal chromophore of visual pigments, whereas RDH8, RDH12, and DHRS3 (retSDR1) catalyze the conversion of all-trans-retinal (atRAL) into all-trans-retinol (atROL) to maintain the cycle (Parker & Crouch 2010). Defects in the RDH5 gene can cause fundus albipunctatus (RPA; MIM:136880), a rare form of stationary night blindness characterised by a delay in the regeneration of cone and rod photopigments (Yamamoto et al. 1999).
Reaction - small molecule participants:
H+ [cytosol]
11cRAL [cytosol]
NADH [cytosol]
11cROL [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-5362721
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Reaction input - small molecules:
11-cis-retinol
NAD(1-)
Reaction output - small molecules:
hydron
11-cis-retinal
NADH(2-)
Reactome.org link: R-HSA-5362721