Reaction: Hh processing variants are translocated to the cytosol in a VCP-dependent manner
- in pathway: Hh mutants are degraded by ERAD
Depletion of the ATPase VCP results in the stabilization of processing-defective Hh variants in the ER lumen, supporting the notion that, as is the case for the WT Hh C-terminal fragment, these peptides are also substrates for ERAD (Chen et al, 2011; Huang et al, 2013).
Reaction - small molecule participants:
phosphate [cytoplasm]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5387389
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
phosphate(3-)
ADP(3-)
Reactome.org link: R-HSA-5387389