Reaction: 39S subunit binds 28S subunit:mRNA:fMet-tRNA
- in pathway: Mitochondrial translation initiation
As inferred from bovine homologs, the 39S ribosomal subunit binds the 28S subunit:mRNA:N-formylmethionyl-tRNA complex, MTIF2 hydrolyzes GTP, then MTIF2, GDP, and MTIF3 dissociate. (MTIF2 has a very low affinity for GDP so it is unclear whether MTIF2 and GDP remain associated after hydrolysis of GTP.) The 28S subunit, 39S subunit, and 55S holoribosome associate with the inner mitochondrial membrane during translation and in the absence of translation.
Reaction - small molecule participants:
Pi [mitochondrial matrix]
GDP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5389839
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Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
GDP(3-)
Reactome.org link: R-HSA-5389839