Reaction: 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP
- in pathway: Mitochondrial translation termination
Binding of the MTRF1L (MTRF1a) termination factor triggers hydrolysis of the peptidyl-tRNA bond by the 39S subunit of the ribosome and release of the translated polypeptide (Soleimanpour-Lichaei et al. 2007, Nozaki et al. 2008, reviewed in Christian and Spremulli 2012). MTRF1L hydrolyzes GTP during the reaction. Stalled ribosomes are rescued by binding of an ICT1 protein in addition to the ICT1 subunit integrated in the 39S subunit (Richter et al. 2010, Akabane et al. 2014).
Reaction - small molecule participants:
Pi [mitochondrial matrix]
GDP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5419271
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Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
GDP(3-)
Reactome.org link: R-HSA-5419271