Reaction: AFXBO binds DNA
- in pathway: Aflatoxin activation and detoxification
Aflatoxin B1 (AFB1), a category I known human carcinogen and the most potent genotoxic agent, is mutagenic in many model systems. Aflatoxin B1 exo-8,9-epoxide (AFXBO) binds to DNA to form the predominant 8,9-dihydro-8-(N7 guanyl)-9-hydroxy-AFB1 (AFB1-N7-Gua) adduct. AFB1-N7-Gua confers the mutagenic properties of the compound (Raney et al. 1993, Bedard & Massey 2006).
Reaction - small molecule participants:
AFXBO [nucleoplasm]
Reactome.org reaction link: R-HSA-5423632
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Reaction input - small molecules:
aflatoxin B1 exo-8,9-epoxide
Reaction output - small molecules:
Reactome.org link: R-HSA-5423632