Reaction: AFXBO hydrolyses non-enzymatically to AFBDHD
- in pathway: Aflatoxin activation and detoxification
The exo- and endo-epoxides of aflatoxin B1 are unstable in water and can undergo rapid non-enzymatic hydrolysis to AFB1-8,9-dihydrodiol (AFBDHD) (Johnson et al. 1997, Guengerich et al. 1998).
Reaction - small molecule participants:
AFBDHD [cytosol]
H2O [cytosol]
AFXBO [cytosol]
Reactome.org reaction link: R-HSA-5423656
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Reaction input - small molecules:
water
aflatoxin B1 exo-8,9-epoxide
Reaction output - small molecules:
aflatoxin B1 8,9-dihydrodiol
Reactome.org link: R-HSA-5423656