Reaction: AFXBO translocates from cytosol to nucleoplasm
- in pathway: Aflatoxin activation and detoxification
For the reactive metabolite aflatoxin B1-exo-8,9-epoxide (AFBO) to react with DNA, it must translocate to the nucleus. This mechanism of translocation is thought to be simple diffusion (Guengerich et al. 1998).
Reaction - small molecule participants:
AFXBO [nucleoplasm]
AFXBO [cytosol]
Reactome.org reaction link: R-HSA-5423728
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Reaction input - small molecules:
aflatoxin B1 exo-8,9-epoxide
Reaction output - small molecules:
aflatoxin B1 exo-8,9-epoxide
Reactome.org link: R-HSA-5423728