Reaction: Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C
- in pathway: Aflatoxin activation and detoxification
An unknown cysteine-S-conjugate N-acetyltransferase (NAT) catalyses the transfer of an acetyl group from acetyl CoA (Ac-CoA) to the exo and endo forms of aflatoxin B1-cysteinyl conjugates (AFXBO-C, AFNBO-C). The resultant N-acetylcysteine-S-conjugate is termed a mercapturic acid which is readily excreted in urine (Hinchman & Ballatori 1994).
Reaction - small molecule participants:
CoA-SH [cytosol]
Ac-CoA [cytosol]
Reactome.org reaction link: R-HSA-5433066
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-5433066