Reaction: DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG
- in pathway: Aflatoxin activation and detoxification
In the formation of mercapturic acid from glutathione conjugates, first a glutamate residue is hydrolysed from the conjugate then a glycine residue (Gly). The dipeptidases 1,2 and 3 (DPEP1,2,3) perform this second hydrolysis. They are membrane-bound, homodimeric enzymes which require zinc ions for activity. DPEP1 has been characterised (Satoh et al. 1993, 1994, Nitanai et al. 2002) whereas DPEP2 and 3 are thought to function as DPEP1 based on similarity.
Reaction - small molecule participants:
Gly [extracellular region]
Reactome.org reaction link: R-HSA-5433067
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Reaction input - small molecules:
Reaction output - small molecules:
glycine zwitterion
Reactome.org link: R-HSA-5433067