Reaction: Formation of MSH2:MSH6 Complex
- in pathway: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
MSH2 and MSH6 are mismatch DNA repair genes that act together as a heterodimer. The MSH6 subunit is responsible for binding the mismatch, which activates MSH2:MSH6 to exchange ADP for ATP, adopt the conformation to allow movement on the DNA, and interact with downstream effectors.
Reaction - small molecule participants:
ADP [nucleoplasm]
Reactome.org reaction link: R-HSA-5444516
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Reaction input - small molecules:
ADP(3-)
Reaction output - small molecules:
Reactome.org link: R-HSA-5444516