Reaction: UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b
- in pathway: ER Quality Control Compartment (ERQC)
The UDP-glucose:glycoprotein glucosyltransferases 1 and 2 (UGGT1 and 2) are able to distinguish proteins with minor folding defects in the ERQC and reglucosylate them, by transferring a glucose (from dolichyl beta-D-glucosyl phosphate, DbGP) onto the alpha 1,3 mannose of the b (or c, not shown here) branch (Arnold et al. 2000, Arnold et al. 2003). The major affinity of these enzymes for proteins with minor folding defects has been demonstrated, but the exact mechanism that enable them to distinguish proteins with major and minor defects is still unknown (Pearse et al. 2008).
Reaction - small molecule participants:
DOLP [endoplasmic reticulum quality control compartment]
DbGP [endoplasmic reticulum quality control compartment]
Reactome.org reaction link: R-HSA-548884
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Reaction input - small molecules:
dolichyl beta-D-glucosyl phosphate
Reaction output - small molecules:
dolichyl phosphate(2-)
Reactome.org link: R-HSA-548884