Reaction: KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region
- in pathway: Phase 1 - inactivation of fast Na+ channels
In phase 1 of the action potential, the fast Na+ channels are inactivated. This happens by net outward currents Ito1 and Ito2 caused by efflux of K+ and Cl- ions respectively. Potassium voltage-gated channel subfamily D members 1, 2 and 3 (KCND1, 2 and 3) are pore-forming (alpha) subunits of voltage-gated, rapidly inactivating A-type K+ channels (Isbrandt et al. 2000) that produce the Ito1 current. They may also contribute to the ISa current in neurons. KCND1 is functional as either a homo- or hetero-tetramer with KCND2 and/or KCND3. KCNDs associate with the regulatory subunits KCNIP1-4 (Scannevin et al. 2004, Pioletti et al. 2006). KCNIPs form homodimers and/or homotetramers (Lin et al. 2004). KCNIPs and KCNDs together modulate the density, inactivation kinetics and rate of recovery from inactivation of KCNDs (An et al. 2000, Nakamura et al. 2001, Shibata et al. 2003, Wang et al. 2007).
Reaction - small molecule participants:
K+ [extracellular region]
K+ [cytosol]
Reactome.org reaction link: R-HSA-5577234
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Reaction input - small molecules:
potassium(1+)
Reaction output - small molecules:
potassium(1+)
Reactome.org link: R-HSA-5577234