Reaction: KCNH2:KCNE transport K+ from cytosol to extracellular region
- in pathway: Phase 3 - rapid repolarisation
Two potassium currents, IKs and IKr, provide the principal repolarising currents in cardiac myocytes for the termination of action potentials. The potassium voltage-gated channel subfamily H member 2 (KCNH2 aka HERG) is the pore-forming alpha subunit of a stable complex with a regulating beta subunit of the potassium voltage-gated channel subfamily E family (KCNE). This stable complex creates the Kr current by the efflux of K+ (Macdonald et al. 1997, Abbott et al. 1999).
Reaction - small molecule participants:
K+ [extracellular region]
K+ [cytosol]
Reactome.org reaction link: R-HSA-5577237
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Reaction input - small molecules:
potassium(1+)
Reaction output - small molecules:
potassium(1+)
Reactome.org link: R-HSA-5577237