Reaction: B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA
- in pathway: O-linked glycosylation
Glycosyltransferase-like protein LARGE2 (GYLTL1B; MIM:609709) is a bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of a phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a structure present in alpha-dystroglycan (DAG1) which plays a key role in skeletal muscle function and regeneration (Inamori et al. 2012, Inamori et al. 2013, Wells 2013). LARGE2 belongs to the CAZy glycosyltransferase families GT8 and GT49.
Reaction - small molecule participants:
Xyl-GlcA-Xyl-GlcA [Golgi lumen]
UDP [Golgi lumen]
GlcA-Xyl-GlcA [Golgi lumen]
UDP-Xyl [Golgi lumen]
Reactome.org reaction link: R-HSA-5617138
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Reaction input - small molecules:
beta-D-GlcA-(1->3)-alpha-D-Xyl-(1->3)-beta-D-GlcA
UDP-alpha-D-xylose(2-)
Reaction output - small molecules:
alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->3)-alpha-D-Xyl-(1->3)-beta-D-GlcA
UDP(3-)
Reactome.org link: R-HSA-5617138