Reaction: CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM)
- in pathway: Dectin-2 family
CLEC4D (Macrophage C-type lectin (MCL)) is a member of the C-type lectin that recognises mycobacterial trehalose-6,6'-dimycolate (TDM) or cord factor likely to arise from gene duplication of CLEC4E (also called Minicle). CLEC4D is constitutively expressed on myeloid cells. It couples with FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) and acts as an activating receptor (Miyake et al. 2013).
Reaction - small molecule participants:
TDM [plasma membrane]
Reactome.org reaction link: R-HSA-5621353
======
Reaction input - small molecules:
trehalose 6,6'-dimycolate
Reaction output - small molecules:
Reactome.org link: R-HSA-5621353