Reaction: CD209 binds ICAM3
- in pathway: CD209 (DC-SIGN) signaling
Contact between dendritic cells (DC) and resting T cells is essential to initiate a primary immune response. CD209 binds the intracellular adhesion molecule 3 (ICAM3) with very high affinity. CD209 interacts primarily with the immunoglobulin (Ig)-like second domain of ICAM2 and ICAM3. CD209-ICAM3 interaction mediates clustering of DCs with naive T cells forming a DC-T cell synapse (Geijtenbeek et al. 2000). CD209 binding to ICAM3 is calcium dependent, and CD209 CRD (carbohydrate recognition domain) binds two Ca2+ ions, one essential for tertiary structure and the other for coordinating ligand binding (Feinberg et al. 2001, Svajger et al. 2010).
Reaction - small molecule participants:
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-5621615
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-5621615