Reaction: RDH13 reduces atRAL to atROL
- in pathway: RA biosynthesis pathway
Multiple reductases may contribute to the reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL). Human retinol dehydrogenase 13 (RDH13) is located on the outer surface of the mitochondrial inner membrane where it is thought to protect mitochondria against oxidative stress associated with the highly reactive retinaldehyde (Belyaeva et al. 2008).
Reaction - small molecule participants:
NADP+ [mitochondrial intermembrane space]
atROL [mitochondrial intermembrane space]
NADPH [mitochondrial intermembrane space]
atRAL [mitochondrial intermembrane space]
H+ [mitochondrial intermembrane space]
Reactome.org reaction link: R-HSA-5623643
======
Reaction input - small molecules:
NADPH
all-trans-retinal
hydron
Reaction output - small molecules:
NADP(+)
all-trans-retinol
Reactome.org link: R-HSA-5623643