Meta-Biol

• Pathways

Protein kinase A (PKA/PRKACA) and Ribosomal protein S6 kinase alpha-5 (RPS6KA5/MSK1/SAPK1) phosphorylate serine 276 (S276) in the Rel homology domain (RHD) of nuclear p65 subunit RELA (Yoon et al. 2008, Reber et al. 2009). Few other phosphorylation sites (S311, S529 and S536) have also been proposed in RELA (Duran et al. 2003) note: in this reaction we are showing only S276 phosphorylation)). Phosphorylation of RELA subunit enhances the association of RELA with p300 and this is a prerequisite for later NF-kB modification by histone acetyltransferases (HATs) p300/CBP. Phosphorylation of RELA also cross-regulates CLEC7A (dectin-1) mediated non-canonical NF-kB pathway by forming inactive p65 and RELB dimers, that cannot bind DNA.