Reaction: SFKs phosphorylates RAF1 on Y340,Y341
- in pathway: CD209 (DC-SIGN) signaling
Phosphorylation of tyrosine 340, 341 (Y340,341) on RAF1 in response to CD209 (DC-SIGN) signalling depends on yet unidentified members of the Src family of tyrosine kinases (SFKs). In imunoprecipitation studies, CD209 from lipid rafts of dendritic cells was found to co-precipitate with LYN, a member of the SFK, as well as with SYK tyrosine kinase, indicating their possible involvement in DC-SIGN signalling (Caparros et al. 2006, Svajger et al. 2010).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5624486
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5624486