Reaction: SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+
- in pathway: Sodium/Calcium exchangers
The five members of the NCKX (SLC24) family are all able to exchange one Ca2+ and one K+ for four Na+. SLC24A5 encodes a trans-Golgi network exchanger protein NCKX5 which is expressed in melanocytes and regulates human epidermal melanogenesis (Ginger et al. 2008).
Reaction - small molecule participants:
K+ [cytosol]
Ca2+ [cytosol]
Na+ [Golgi lumen]
K+ [Golgi lumen]
Na+ [cytosol]
Ca2+ [Golgi lumen]
Reactome.org reaction link: R-HSA-5626316
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Reaction input - small molecules:
potassium(1+)
sodium(1+)
calcium(2+)
Reaction output - small molecules:
potassium(1+)
calcium(2+)
sodium(1+)
Reactome.org link: R-HSA-5626316