Reaction: SLC26A3 does not exchange Cl- for HCO3-
Solute carrier (SLC) genes that code chloride (Cl-)/bicarbonate (HCO3-) exchanger proteins are the SLC4 and SLC26 families. The chloride anion exchanger SLC26A3 (aka down-regulated in adenoma, DRA) mediates electrolyte and fluid absorption in the colon. Defects in SLC26A3 cause congenital chloride diarrhea 1 (DIAR1), a disease characterised by watery stools containing an excess of chloride resulting in dehydration, hypokalemia, and metabolic alkalosis. Mutations in SLC26A3 causing DIAR1 include W462*, G187*, I675dup and V317del (Hoglund et al. 1996, 1998, Makela et al. 2002).
Reaction - small molecule participants:
Cl- [extracellular region]
HCO3- [cytosol]
Reactome.org reaction link: R-HSA-5627737
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Reaction input - small molecules:
chloride
hydrogencarbonate
Reaction output - small molecules:
Reactome.org link: R-HSA-5627737