Reaction: BRD7 promotes EP300-mediated acetylation of TP53
- in pathway: Regulation of TP53 Activity through Acetylation
BRD7 promotes EP300 (p300)-mediated acetylation of TP53 on lysine residue K382, which enhances binding of TP53 to its target promoters. Also, BRD7 induces EP300-mediated acetylation of histone 3 on lysine residue K10 (also labeled in literature as K9), creating the H3K9 active chromatin mark at CDKN1A and MDM2 promoters (Drost et al. 2010), and possibly other TP53 promoters co-regulated by BRD7, such as SERPINE1, TIGAR, TNFRSF10C and NDRG1.
Reaction - small molecule participants:
CoA-SH [nucleoplasm]
Ac-CoA [nucleoplasm]
Reactome.org reaction link: R-HSA-5628871
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-5628871