Reaction: NEIL1 cleaves FapyA from damaged DNA
- in pathway: Cleavage of the damaged pyrimidine
NEIL1 acts as a DNA glycosylase to remove FapyA from damaged DNA, producing an AP (apurinic/apyrimidinic) site (Hazra et al. 2002).
Reaction - small molecule participants:
FapyA [nucleoplasm]
Reactome.org reaction link: R-HSA-5649673
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Reaction input - small molecules:
Reaction output - small molecules:
4,6-diamino-5-formamidopyrimidine
Reactome.org link: R-HSA-5649673