Reaction: NEIL2 cleaves 5-OHU from damaged DNA
- in pathway: Cleavage of the damaged pyrimidine
NEIL2 acts as a DNA glycosylase to cleave 5'-hydroxyuracil from damaged DNA, producing an AP (apurinic/apyrimidinic) site (Hazra et al. 2002).
Reaction - small molecule participants:
5-OHU [nucleoplasm]
Reactome.org reaction link: R-HSA-5649681
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Reaction input - small molecules:
Reaction output - small molecules:
5-hydroxyuracil
Reactome.org link: R-HSA-5649681