Reaction: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution
- in pathway: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
POLB (DNA polymerase beta) incorporates a single nucleotide to extend the PNKP-processed 3' end of the single strand break (SSB) generated by the beta/delta lyase activity of NEIL1 or NEIL2. POLB thus replaces the excised AP (apurinic/apyrimidinic) deoxyribose phosphate residue (5'dRP) (Wiederhold et al. 2004, Das et al. 2006).
Reaction - small molecule participants:
PPi [nucleoplasm]
dNTP [nucleoplasm]
Reactome.org reaction link: R-HSA-5649723
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Reaction input - small molecules:
2'-deoxyribonucleoside triphosphate
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-5649723