Reaction: POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)
- in pathway: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
POLB (DNA polymerase beta) acts as a 5'-exonuclease to remove the abasic deoxyribose residue (5'dRP) generated by the DNA glycosylase and/or beta/delta lyase activity of NEIL1 or NEIL2, producing a single nucleotide gap at the SSB (single strand break) site (Wiederhold et al. 2004, Das et al. 2006). The NEIL1 or NEIL2-generated SSB has a 3' terminal phosphate (3'Pi).
Reaction - small molecule participants:
SUGP [nucleoplasm]
Reactome.org reaction link: R-HSA-5649725
======
Reaction input - small molecules:
Reaction output - small molecules:
phospho sugar
Reactome.org link: R-HSA-5649725