Reaction: PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate
- in pathway: POLB-Dependent Long Patch Base Excision Repair
PARP1 or PARP2 homodimers or heterodimers, bound to single strand DNA (ssDNA), POLB and FEN1 at the single strand break (SSB), undergo progressive auto-PARylation causing PARP1/PARP2 to become poly(ADP-ribosyl)ated (Satoh et al. 1994, Prasad et al. 2001).
Reaction - small molecule participants:
NAM [nucleoplasm]
NAD+ [nucleoplasm]
Reactome.org reaction link: R-HSA-5651723
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
Reactome.org link: R-HSA-5651723