Reaction: PARG dePARylates PARP1,PARP2
- in pathway: POLB-Dependent Long Patch Base Excision Repair
PARG acts as a poly(ADP-ribosyl)glycohydrolase (PAR glycohydrolase) that reverses auto(ADP-ribosyl)ation of PARP1 and/or PARP2 (Kim et al. 2004). PARG activity is required for the turnover of PARP1 and/or PARP2, which allows for the rapid completion of the single strand break (SSB) repair (Fisher et al. 2007). PARG may be recruited to DNA damage site through PCNA binding (Mortusewicz et al. 2011).
Reaction - small molecule participants:
ADP-D-ribose [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5651828
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Reaction input - small molecules:
water
Reaction output - small molecules:
ADP-D-ribose
Reactome.org link: R-HSA-5651828