Reaction: SORD oxidizes D-sorbitol to Fru
- in pathway: Fructose biosynthesis
Cytosolic SORD (sorbitol dehydrogenase) catalyzes the reaction of D-sorbitol and NAD+ to form fructose (Fru) and NADH + H+. This reaction was first described by Hers (1960) in sheep seminal vesicles; the human enzyme was identified by O'Brien et al. (1983). The active enzyme is a tetramer with four associated Zn2+ ions (Pauly et al. 2003) whose amino-terminal methionine residue has been removed (Karlsson et al. 1989).
Reaction - small molecule participants:
H+ [cytosol]
keto-D-Fru [cytosol]
NADH [cytosol]
D-sorbitol [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-5652195
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Reaction input - small molecules:
D-glucitol
NAD(1-)
Reaction output - small molecules:
hydron
keto-D-fructose
NADH(2-)
Reactome.org link: R-HSA-5652195