Reaction: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA
- in pathway: Termination of translesion DNA synthesis
USP10 acts as a ubiquitin protease to remove ubiquitin from lysine K164 residue of doubly ISGylated PCNA. Deubiquitination of PCNA by USP10 causes dissociation of Y family DNA damage bypass polymerases, thus ending translesion DNA synthesis (TLS) and limiting TLS-induced mutagenesis (Park et al. 2014).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5653770
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5653770