Reaction: POLD,POLE complete replication of damaged DNA after TLS
- in pathway: Termination of translesion DNA synthesis
After DNA damage is bypassed by error-prone DNA polymerases capable of translesion DNA synthesis (TLS), the replicative complex composed of PCNA, DNA polymerases delta (POLD) or epsilon (POLE), RPA and RFC, completes the replication of damaged DNA (Park et al. 2014). Replicated damaged DNA may then be repaired through base excision or another DNA repair mechanism before the next round of DNA replication.
Reaction - small molecule participants:
PPi [nucleoplasm]
dNTP [nucleoplasm]
Reactome.org reaction link: R-HSA-5653840
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Reaction input - small molecules:
2'-deoxyribonucleoside triphosphate
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-5653840