Reaction: POLZ elongates POLI-incorporated dNMP
- in pathway: Translesion synthesis by POLI
After it incorporates a dNMP opposite to a damaged template base, DNA polymerase iota (POLI) is unable to efficiently elongate the DNA strand further. The elongation step is performed by the DNA polymerase zeta complex (POLZ), composed of REV3L and MAD2L2 subunits (Johnson et al. 2000). POLK has also been implicated in the elongation step (Washington et al. 2004).
Reaction - small molecule participants:
PPi [nucleoplasm]
dNTP [nucleoplasm]
Reactome.org reaction link: R-HSA-5656158
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Reaction input - small molecules:
2'-deoxyribonucleoside triphosphate
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-5656158