Reaction: MT1A binds zinc
- in pathway: Metallothioneins bind metals
The MT1A metallothionein binds 7 zinc(II) atoms, 3 at the N-terminal beta domain and 4 at the C-terminal alpha domain (Sunderland et al. 2012). Binding is non-cooperative (Sunderland et al. 2012) and occurs via thiolate bonds between zinc and cysteine residues of the protein. MT1A binds 5 atoms of zinc before clustering of the zinc occurs (Summers et al. 2013). The 2 remaining zinc atoms bind MT1A with significantly less affinity (Summers et al. 2013).
Reaction - small molecule participants:
Zn2+ [cytosol]
Reactome.org reaction link: R-HSA-5661217
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Reaction input - small molecules:
zinc(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-5661217