Reaction: KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose
- in pathway: Formation of xylulose-5-phosphate
Cytosolic dehydro-L-gulonate decarboxylase (KGPDC) catalyzes the conversion of 3-dehydro-L-gulonate to L-xylulose and CO2. Studies in vivo provide indirect but strong evidence that this reaction occurs in humans and guinea pigs and dehydro-L-gulonate decarboxylase enzyme has been partially purified from guinea pigs (Winkelman & Ashwell 1961). Its amino acid sequence is unknown, however.
Reaction - small molecule participants:
CO2 [cytosol]
L-xylulose [cytosol]
3-dehydro-L-gulonate [cytosol]
Reactome.org reaction link: R-HSA-5662473
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Reaction input - small molecules:
3-dehydro-L-gulonate
Reaction output - small molecules:
carbon dioxide
L-xylulose
Reactome.org link: R-HSA-5662473