Reaction: MT2A binds zinc
- in pathway: Metallothioneins bind metals
The metallothionein MT2A binds 7 atoms of zinc(II) in two clusters, one at the N-terminal beta domain and one at the C-terminal alpha domain (Stillman et al. 2000, Yang et al. 2007). The cluster at the alpha domain is more stable than the cluster at the beta domain, making the beta domain a better zinc donor (Jiang et al. 2000). Each cluster assembles independently (Jiang et al. 2000).
Reaction - small molecule participants:
Zn2+ [cytosol]
Reactome.org reaction link: R-HSA-5662598
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Reaction input - small molecules:
zinc(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-5662598