Reaction: MT3 exchanges zinc for copper
- in pathway: Metallothioneins bind metals
MT3:7Zn2+ releases 3 zinc ions and binds 4 copper ions at the N-terminal beta domain (Roschitszi et al. 2003, Meloni et al. 2007, Meloni et al. 2008). By this mechanism MT3 is able to scavenge free copper ions and swap metal with an aggregated amyloid beta:copper(II) complex and a alpha-synuclein:copper(II) complex and thereby abolish production of reactive oxygen species (Meloni et al. 2008, Meloni and Vasak 2011, Pedersen et al. 2012, Luo et al. 2013). The copper ions are divalent (copper(II), Cu2+) before binding but univalent (copper(I), Cu1+) after binding (Meloni et al. 2008).
Reaction - small molecule participants:
Zn2+ [cytosol]
Cu2+ [cytosol]
Reactome.org reaction link: R-HSA-5662613
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Reaction input - small molecules:
copper(2+)
Reaction output - small molecules:
zinc(2+)
Reactome.org link: R-HSA-5662613