Reaction: Dopaquinone transforms to Leucodopachrome (Cyclodopa)
- in pathway: Melanin biosynthesis
Dopaquinone is highly reactive and in the absence of sulfhydryl compounds it undergoes the intramolecular addition of the amino group to produce an intermediate, leucodopachrome (also termed cyclodopa). A redox exchange between cyclodopa and dopaquinone then gives rise to dopachrome, an orange-red intermediate (Raper 1927, Mason et al. 1948) and dopa. This latter reaction is considered the source of dopa formed during melanogenesis (Ito & Wakamatsu 2008).
Reaction - small molecule participants:
Leucodopachrome [melanosome lumen]
L-Dopaquinone [melanosome lumen]
Reactome.org reaction link: R-HSA-5662669
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Reaction input - small molecules:
L-dopaquinone
Reaction output - small molecules:
leucodopachrome
Reactome.org link: R-HSA-5662669