Reaction: Dopachrome transforms to DHI
- in pathway: Melanin biosynthesis
Dopachrome spontaneously tautomerizes into 5,6-dihydroxyindole (DHI) via decarboxylation at physiological pH (Mason et al. 1948, Wakamatsu & Ito 1988, Kishida et al. 2015). This is usually a minor process of melanin synthesis in vivo. However, in human hair follicular melanocytes, it predominates (Commo et al. 2012).
Reaction - small molecule participants:
DHI [melanosome lumen]
CO2 [melanosome lumen]
Dopachrome [melanosome lumen]
Reactome.org reaction link: R-HSA-5662706
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Reaction input - small molecules:
dopachrome
Reaction output - small molecules:
5,6-dihydroxyindole
carbon dioxide
Reactome.org link: R-HSA-5662706