Reaction: MT3 binds copper
- in pathway: Metallothioneins bind metals
The metallothionein MT3 is able to bind 12 copper(I) atoms when fully saturated (Roschitzki et al. 2002). Initially, 4 copper(I) atoms bind to each of the alpha and beta domains followed by the binding of 4 more copper(I) atoms. As inferred from the mouse homolog, MT3 exhibits a Cu-thionein character stronger than that of the MT1 and MT2 isoforms and it displays a high capacity to bind Cu+ provided that this occurs in a non-oxidative milieux.
Reaction - small molecule participants:
Cu1+ [cytosol]
Reactome.org reaction link: R-HSA-5663002
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Reaction input - small molecules:
copper(1+)
Reaction output - small molecules:
Reactome.org link: R-HSA-5663002