Reaction: NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors
- in pathway: Heme signaling
NR1D1 (REV-ERBA) binds the promoter of the NPAS2 gene and recruits corepressors to repress transcription. Recruitment of repressors appears to depend on the binding of heme by NR1D1.
Reaction - small molecule participants:
ferriheme b [nucleoplasm]
ferriheme b [nucleoplasm]
Reactome.org reaction link: R-HSA-5663245
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Reaction input - small molecules:
ferriheme b
ferriheme b
Reaction output - small molecules:
Reactome.org link: R-HSA-5663245