Reaction: NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors
- in pathway: Heme signaling
NR1D1 (REV-ERBA) binds heme and the promoter of the PGC-1alpha (PPARGC1A) gene. The REV-ERBA:heme complex recruits the corepressors NCoR and HDAC3 and represses transcription.
Reaction - small molecule participants:
ferriheme b [nucleoplasm]
ferriheme b [nucleoplasm]
Reactome.org reaction link: R-HSA-5663258
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Reaction input - small molecules:
ferriheme b
ferriheme b
Reaction output - small molecules:
Reactome.org link: R-HSA-5663258