Reaction: AURKB phosphorylates DIAPH2-2 at kinetochores
- in pathway: RHO GTPases Activate Formins
Aurora kinase B (AURKB), which is part of the kinetochore, phosphorylates DIAPH2-2 (DIA-12C, mDia3) on serine residue S196 in the FH3 (DID) domain and probably on several other residues in the FH3 and FH2 domains. AURKB-mediated phosphorylation of DIAPH2-2 is necessary for the regulation of microtubule binding to kinetochores by the CDC42:GTP:DIAPH2-2 complex (Cheng et al. 2011).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5666160
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5666160