Reaction: PAK2 phosphorylates myosin regulatory light chain (MRLC)
- in pathway: RHO GTPases activate PAKs
PAK2, activated by CDC42 or RAC1 RHO GTPases, phosphorylates myosin regulatory light chain (MRLC, MYL9 or MYL12B) of the non-muscle myosin II complex on threonine residue T19 (also labeled in literature as T18). This leads to the rearrangement of the actin cytoskeleton and cell retraction (Chew et al. 1998, Zeng et al. 2000).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5668932
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5668932