Reaction: p-T774-PKN1 phosphorylates PPP1R14A
- in pathway: RHO GTPases activate PKNs
Activated PKN1 (p-T774-PKN1) phosphorylates PPP1R14A (CPI-17), an inhibitor of myosin light chain phosphatase complex (MLPC), on threonine residue T38 (Hamaguchi et al. 2000), and high levels of PKN1 activity correlate with high levels of PPP1R14A phosphorylation (Lartey et al. 2007). It is not certain that PKN1 can directly bind PPP1R14A, and C family protein kinases (PKCs) may be the main PPP1R14A kinases (Zemlickova et al. 2004).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5671763
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5671763