Reaction: PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA
- in pathway: Synthesis of very long-chain fatty acyl-CoAs
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratases 1-4 (PTPLA, B, D1 and D2 respectively, aka HACD1-4) mediate the dehydration step in VLCFA synthesis. A very-long-chain (3R)-3-hydroxyacyl-CoA (VLC3HA-CoA) is dehydrated to a very-long-chain 2,3-trans-enoyl CoA (2,3-TE-CoA) (Ikeda et al. 2008).
Reaction - small molecule participants:
H2O [cytosol]
2,3-TE-CoA [cytosol]
VLC3HA-CoA [cytosol]
Reactome.org reaction link: R-HSA-5676637
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Reaction input - small molecules:
(R)-3-hydroxyacyl-CoA
Reaction output - small molecules:
water
trans-2-enoyl-CoA
Reactome.org link: R-HSA-5676637