Reaction: MRSBs reduce L-methyl-(R)-S-oxide to L-methionine
- in pathway: Protein repair
Methionine Sulfoxide Reductase B (MSRBs) are able to reduce methyl-(R)-S-oxide to methionine (Grimaud et al. 2001). They are specific for the reduction of protein-based methyl-(R)-S-oxide, reducing free methyl-(R)-S-oxide with very low efficiency (Lee et al. 2009). Mammals have at least 3 MSRB genes (Kryukov et al. 1999, Huang et al. 1999, Jung et al. 2002, Kim & Gladyshev 2004). They are ubiquitously expressed, no clear substrate specificities are known, all three contain a zinc atom and can use thioredoxin as an in vivo reducing agent (Kim & Gladyshev 2007).
Reaction - small molecule participants:
L-Met [cytosol]
L-methionine (R)-S-oxide [cytosol]
Reactome.org reaction link: R-HSA-5676917
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Reaction input - small molecules:
L-methionine (R)-S-oxide
Reaction output - small molecules:
L-methionine zwitterion
Reactome.org link: R-HSA-5676917