Reaction: ABCC2 transports BMG,BDG from cytosol to extracellular region
- in pathway: Heme degradation
Canalicular multispecific organic anion transporter 1 (ABCC2 aka multidrug resistance-associated protein 2, MRP2), in addition to transporting many organic anions, mediates the ATP-dependent transport of glutathione and glucuronate conjugates from hepatocytes into bile. In the reaction annotated here, ABCC2 specifically transports, with high affinity and efficiency, mono- and di-glucuronated bilirubin (BMG, BDG respectively) into bile (Kamisako et al. 1999). ABCC2 is located on the canalicular membrane of hepatocytes. Bilirubin, the end product of heme breakdown, is an important constituent of bile and is responsible for its characteristic colour.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5679041
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-5679041