Reaction: ULK1 phosphorylates Beclin-1
- in pathway: Macroautophagy
Following amino-acid starvation or mTOR inhibition, activated ULK1 phosphorylates BECN1 (Beclin-1) on Ser-15, thereby enhancing the activity of PIK3C3 (Vps34) in the Beclin-1 complex. This phosphorylation is required for full autophagic induction in mammals (Russell et al. 2013).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5679205
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5679205